Cellular Hypoxia of Pancreatic -Cells Due to High Levels of Oxygen Consumption for Insulin Secretion in Vitro*
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چکیده
Yoshifumi Sato, Hiroko Endo, Hiroaki Okuyama, Takaaki Takeda, Hiromi Iwahashi, Akihisa Imagawa, Kazuya Yamagata, Iichiro Shimomura, and Masahiro Inoue From the Department of Biochemistry, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1-3-3 Nakamichi, Higashinari-ku, Osaka 537-8511, the Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, and the Department of Medical Biochemistry, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan
منابع مشابه
Cellular hypoxia of pancreatic beta-cells due to high levels of oxygen consumption for insulin secretion in vitro.
Cellular oxygen consumption is a determinant of intracellular oxygen levels. Because of the high demand of mitochondrial respiration during insulin secretion, pancreatic β-cells consume large amounts of oxygen in a short time period. We examined the effect of insulin secretion on cellular oxygen tension in vitro. We confirmed that Western blotting of pimonidazole adduct was more sensitive than ...
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تاریخ انتشار 2011